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Updated: Sep 14, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
[Depression in rheumatic diseases or somatic symptoms in depression]
Abstract:
Depression can be produced in many different ways. Via cerebral nuclear-specific imbalance a depression can be associated with disturbances in nuclear regions regulating muscular tone. Such syndromes appear chiefly as syndromes of the cervical vertebral column or lumbal vertebral column or as a general "non-specific-pain-syndrome". Depression may also cause manifestations of "latent" rheumatic complaints by lowering the pain threshold. Chronic physical diseases may be assumed to produce depression via the "common pathway" (nuclear-specific imbalance of biogenic amines). Masked depression can assume the pattern of rheumatic pain syndrome and might be treated as such for a long time purely somatically (i.e. non-effectively because non-specifically).
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