Neurophysiological evidence for different types of depression
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Updated: Aug 18, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
Abstract:
A brief, selective review of a broad range of evidence bearing upon biological distinctions between neurotic and psychotic forms of depression is presented. It includes a somewhat detailed presentation of clinical neurophysiological findings obtained in the author's laboratory over three decades of research. The available evidence is taken to support the discontinuity position of the continuity-discontinuity controversy about neurotic vs psychotic depression. It is concluded that more than one process underlies clinical depression, and that there may be several kinds of depressive disorders.
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