Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra.

International journal of impotence research·2004

Common to both academia and industry: the challenge of discovery. An interview with Perry Molinoff.

Molecular interventions·2004

Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction.

International journal of impotence research·2004

PT-141: a melanocortin agonist for the treatment of sexual dysfunction.

Annals of the New York Academy of Sciences·2003

Specific activation of the alpha 7 nicotinic acetylcholine receptor by a quaternary analog of cocaine.

Molecular pharmacology·2001

Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels.

Nature medicine·2001

Glucocorticoid-induced METTL3 promotes SONFH by enhancing MEG3 m6A methylation and subsequent ABL2 upregulation.

Life sciences·2026

Artemether (an artemisinin derivative) suppresses hepatic gluconeogenesis in diabetic mice by activating miR-155-C/EBPβ axis.

Life sciences·2026

Lactylation and oxidative stress in diabetic retinopathy: Emerging links among metabolic reprogramming, epigenetic regulation and therapeutic potential.

Life sciences·2026

Co-administration of empagliflozin and curcumin attenuates the development of MASLD by modulating lipid metabolism and adipose tissue browning in HFD-fed C57BL/6J mice.

Life sciences·2026

MKL1 promotes intestinal epithelial repair by regulating proliferation, migration, and adhesion.

Life sciences·2026

Liver sinusoidal endothelial cells phenotypes as early predictors of sepsis-associated liver dysfunction.

Life sciences·2026

Strategic synthesis, antibacterial evaluation and SAR analysis of bisindole-chromone hybrids as an anti-staphylococcal agent.

RSC medicinal chemistry·2026

Systematic Structure-Activity Relationship Investigation on Novel 5‑Alkyl-6-benzyl-2-{[(methylthio/phenylthio)alkyl]thio}-pyrimidin-4(3H)‑ones Endowed with Potent Anti-HIV‑1 Activity.

ACS omega·2026

Extraction of Phenolic Compounds from the Pulp of Myrciaria dubia Using Eco-Friendly Solvents: Extraction Kinetics and Determination of Mass Transfer and Thermodynamic Parameters.

ACS omega·2026

Design and synthesis of carbazole-acrylamide-pyridinium hybrids as dual acetylcholinesterase/butyrylcholinesterase inhibitors and evaluation of their cytotoxic profile on SH-SY5Y and HEK293 cell lines.

RSC medicinal chemistry·2026

A quantitative screening strategy based on activity-content ratio for prioritizing bioactive compounds in medicinal plants.

Journal of pharmaceutical analysis·2026

Correction: Molecular networks and bioactivity-guided discovery of aliphatic derivatives from marine-derived fungus Talaromyces sp.

RSC advances·2026

Related Experiment Videos

Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

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Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra.

Common to both academia and industry: the challenge of discovery. An interview with Perry Molinoff.

Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction.

PT-141: a melanocortin agonist for the treatment of sexual dysfunction.

Specific activation of the alpha 7 nicotinic acetylcholine receptor by a quaternary analog of cocaine.

Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels.

Glucocorticoid-induced METTL3 promotes SONFH by enhancing MEG3 m6A methylation and subsequent ABL2 upregulation.

Artemether (an artemisinin derivative) suppresses hepatic gluconeogenesis in diabetic mice by activating miR-155-C/EBPβ axis.

Lactylation and oxidative stress in diabetic retinopathy: Emerging links among metabolic reprogramming, epigenetic regulation and therapeutic potential.

Co-administration of empagliflozin and curcumin attenuates the development of MASLD by modulating lipid metabolism and adipose tissue browning in HFD-fed C57BL/6J mice.

MKL1 promotes intestinal epithelial repair by regulating proliferation, migration, and adhesion.

Liver sinusoidal endothelial cells phenotypes as early predictors of sepsis-associated liver dysfunction.

Strategic synthesis, antibacterial evaluation and SAR analysis of bisindole-chromone hybrids as an anti-staphylococcal agent.

Systematic Structure-Activity Relationship Investigation on Novel 5‑Alkyl-6-benzyl-2-{[(methylthio/phenylthio)alkyl]thio}-pyrimidin-4(3H)‑ones Endowed with Potent Anti-HIV‑1 Activity.

Extraction of Phenolic Compounds from the Pulp of Myrciaria dubia Using Eco-Friendly Solvents: Extraction Kinetics and Determination of Mass Transfer and Thermodynamic Parameters.

Design and synthesis of carbazole-acrylamide-pyridinium hybrids as dual acetylcholinesterase/butyrylcholinesterase inhibitors and evaluation of their cytotoxic profile on SH-SY5Y and HEK293 cell lines.

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Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

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