Effects of a potent and specific beta 2-adrenoceptor antagonist on intraocular pressure

1 Physiological studies support the possibility of adrenergic regulation of aqueous humor secretion from the ciliary process, a tissue which has recently been shown to contain a predominance of beta 2-adrenoceptors. 2 The present experiments examine the effects of a potent and highly specific beta 2-antagonist (IPS 339) on intraocular pressure in the normal rabbit eye. 3 The observed decrease in pressure caused by IPS 339 suggests that highly specific beta 2-antagonists may be useful in decreasing elevated intraocular pressure.