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Antihypertensive effect of E-643, a new alpha-adrenergic blocking agent
European Journal of Clinical Pharmacology
|January 1, 1981
Summary
E-643, an alpha-blocking agent, effectively lowered blood pressure in hypertensive patients across supine, sitting, and standing positions. While pulse rate increased in upright positions, plasma hormone levels remained unchanged.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Hypertension Research
Background:
- Essential hypertension remains a significant global health concern.
- Alpha-blocking agents are a class of drugs used to manage hypertension.
- Understanding the efficacy and side effect profile of new antihypertensive agents is crucial.
Purpose of the Study:
- To evaluate the blood pressure-lowering effects of E-643, a novel alpha-blocking agent, in patients with essential hypertension.
- To assess the impact of E-643 on blood pressure irrespective of patient posture (supine, sitting, standing).
- To investigate the influence of E-643 on plasma catecholamine and hormone levels.
Main Methods:
- A 7-day treatment study involving 15 inpatients (8 male, 7 female) with essential hypertension.
- Daily administration of 1 mg E-643, three times daily.
- Blood pressure and pulse rate measurements in supine, sitting, and standing positions.
- Plasma levels of noradrenaline, adrenaline, dopamine-beta-hydroxylase, renin, and aldosterone were measured before and after treatment.
Main Results:
- Significant reductions in systolic and diastolic blood pressure were observed in all measured positions (supine, sitting, standing).
- Pulse rate increased in sitting and standing positions but remained unaffected in the supine position.
- No significant changes were noted in plasma levels of adrenaline, noradrenaline, dopamine-beta-hydroxylase, renin, or aldosterone.
- Antihypertensive effects were more pronounced in patients with higher baseline plasma catecholamines and dopamine-beta-hydroxylase levels.
Conclusions:
- E-643 demonstrates significant antihypertensive efficacy across different postures in patients with essential hypertension.
- The drug's effect on blood pressure is not associated with significant alterations in key plasma hormone levels.
- While transient side effects like dizziness were reported, E-643 appears to be a promising agent for hypertension management.