Related Experiment Video

Updated: Nov 8, 2025

Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes
09:17

Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes

Published on: August 9, 2022

2.3K

Influence of isoproterenol and propranolol on human intestinal transport in vivo

A I Morris, L A Turnberg

    Gastroenterology
    |December 1, 1981
    PubMed

    We have studied the effects of a beta-adrenergic agonist and antagonist on transmucosal transport in the human jejunum and ileum in vivo. Using a triple lumen perfusion technique we have demonstrated that intravenous isoproterenol significantly increased absorption of sodium, chloride, and water in both the jejunum and ileum, and of potassium in the ileum. Beta blockade with intravenous propranolol significantly reduced jejunal electrolyte absorption and induced ileal water and sodium secretion. Isoproterenol reduced pressure wave activity in 6 of 8 subjects while propranolol was without any consistent motor effect. These results support a role for the beta-adrenergic division of the autonomic nervous system in the control of intestinal transport in humans.

    More Related Videos

    Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis08:05

    Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

    Published on: May 19, 2021

    3.9K
    Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice05:08

    Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

    Published on: October 3, 2019

    11.5K

    Related Concept Videos

    Carrier-Mediated Transport01:06

    Carrier-Mediated Transport

    Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
    Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
    729
    Methods for Studying Drug Absorption: In situ01:09

    Methods for Studying Drug Absorption: In situ

    In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
    The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
    453
    Methods for Studying Drug Absorption: In vitro01:16

    Methods for Studying Drug Absorption: In vitro

    In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
    The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
    434
    Hepatic Drug Clearance: Role of Transporters01:14

    Hepatic Drug Clearance: Role of Transporters

    In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
    160
    Adrenergic Receptors: β Subtype01:26

    Adrenergic Receptors: β Subtype

    β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
    Isoprenaline > Adrenaline > Noradrenaline
    Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
    β1-adrenoceptors: β1-adrenoceptors...
    2.9K
    Antihypertensive Drugs: Types of β-Blockers01:28

    Antihypertensive Drugs: Types of β-Blockers

    β receptors are classified into three subclasses: β1, β2, and β3. β1 receptors are primarily located in the heart and kidneys. When they get activated, they increase heart rate, contractility, and renin release. This process enhances blood pressure and aids in stress management. In contrast, β2 receptors are situated mainly in the lungs, blood vessels, and skeletal muscles. Upon activation, they trigger smooth muscle relaxation, causing bronchodilation and...
    1.2K