Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Alpha blockers and microcirculation (author's transl)].

M Cloarec, B Graisely, G Perdriset

    Journal Des Maladies Vasculaires
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    GliSODin, a vegetal sod with gliadin, as preventative agent vs. atherosclerosis, as confirmed with carotid ultrasound-B imaging.

    European annals of allergy and clinical immunology·2007
    Same author

    A pharmacodynamic study of clopidogrel in chronic hemodialysis patients.

    Journal of thrombosis and thrombolysis·2000
    Same author

    [Anatomic and functional features of venous valves].

    Journal des maladies vasculaires·1997
    Same author

    Short-term evaluation of plaque area measurement reproducibility from computer-assisted sonography.

    Angiology·1995
    Same author

    Evaluation of ifenprodil efficacy on exercise-induced tissue ischemia in stage II arteriopathy by measurement of transcutaneous oxygen tension during a standard treadmill test: double-blind study of injectable ifenprodil versus placebo.

    Angiology·1993
    Same author

    [Venous pain, 30 years after the 1st International Congress of Phlebology in Chambéry].

    Phlebologie·1992
    Same journal

    Renal function and venous thromboembolic diseases.

    Journal des maladies vasculaires·2016
    Same journal

    [Ankle-brachial index screening for peripheral artery disease in high cardiovascular risk patients. Prospective observational study of 370 asymptomatic patients at high cardiovascular risk].

    Journal des maladies vasculaires·2016
    Same journal

    [Erratum to "When to worry about before a vascular chronic leg ulcer?" [J. Mal. Vasc. 41 (2016) 307-314]].

    Journal des maladies vasculaires·2016
    Same journal

    [Deep venous thrombosis of the upper limb in a violin player: The "bow syndrome"].

    Journal des maladies vasculaires·2016
    Same journal

    [Economic consequences of biological monitoring and medical complications of injectable anticoagulants in France].

    Journal des maladies vasculaires·2016
    Same journal

    [Vitamin K antagonist, direct oral anticoagulants: Where is the truth?]

    Journal des maladies vasculaires·2016
    See all related articles

    Prazosin, an antihypertensive agent, primarily affects vascular smooth muscle to lower blood pressure. Studies show it does not significantly alter microcirculation in hypertensive patients but offers limited benefit for Raynaud phenomenon.

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • Vascular Biology

    Context:

    • Prazosin is an established antihypertensive agent.
    • Its mechanism involves alpha-adrenergic blockade, impacting vascular tone.
    • The study investigates Prazosin's effects on microcirculation and vasospastic conditions.

    Purpose:

    • To evaluate the efficacy of Prazosin in modifying microcirculation.
    • To assess Prazosin's therapeutic potential in patients with hypertensive disease and Raynaud phenomenon.

    Summary:

    • Fourteen patients treated with Prazosin underwent capillaroscopy, ultrasonic investigations, and plethysmography.
    • No significant microcirculatory changes were observed in seven hypertensive patients.
    • Among seven Raynaud phenomenon patients, only one with Buerger disease showed a good response; two others had minimal fingertip blood flow increase.

    Related Experiment Videos

    Impact:

    • Prazosin's direct action on vascular smooth muscle effectively reduces total peripheral resistance.
    • Findings suggest limited efficacy of Prazosin in improving microcirculation for hypertensive patients.
    • The drug shows minimal benefit for Raynaud phenomenon, with a notable exception in Buerger disease.