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Migraine: a platelet disorder

E Hanington, R J Jones, J A Amess

    Lancet (London, England)
    |October 3, 1981
    PubMed

    Insights

    Migraine patients show abnormal platelet behavior, including increased aggregation and adhesion. Reduced serotonin release after attacks suggests platelet differences contribute to migraine onset and recurrence.

    Area of Science:

    • Neurology
    • Hematology
    • Biomedical Science

    Background:

    • Migraine is a common neurological disorder.
    • The underlying pathophysiology of migraine remains incompletely understood.
    • Platelet behavior has been implicated in various vascular and neurological conditions.

    Purpose of the Study:

    • To investigate the hypothesis that primary abnormalities in platelet behavior contribute to migraine.
    • To compare platelet function in migraine patients versus healthy controls.

    Main Methods:

    • Studied 77 individuals, including migraine patients and control subjects.
    • Assessed spontaneous platelet aggregation and platelet adhesion.
    • Measured platelet 5-hydroxytryptamine (serotonin) release during headache-free periods and after migraine attacks.

    Main Results:

    • Platelets from migraine patients exhibited significantly higher spontaneous aggregation and adhesion compared to controls.
    • Platelet serotonin release was significantly lower within three days following a migraine attack than during headache-free intervals.
    • Distinct differences in platelet behavior were observed between migraine patients and healthy individuals.

    Conclusions:

    • Platelet behavior in migraine patients differs significantly from that of normal individuals.
    • These observed platelet abnormalities may play a crucial role in the initiation and recurrence of migraine attacks.
    • Further research into platelet function could offer new therapeutic targets for migraine management.

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