[A non-invasive clinical-pharmacological method for measuring the beta-adrenolytic activity (author's transl)]

Description of a non invasive model to determine the negative-chronotropic effect, which leads to well stabilized parameters by tailoring. Basis of the model is the work-induced tachycardia at which the work-induced increase of frequency is measured at a specified time after 10 preliminary ergometries for the elimination of training effects. The parameter for the effect is the difference of frequencies at nominal time before and after administration of beta-adrenolytic drug. The relevance of the model is shown at the example of acebutolol (Neptal 400) in various high dosages.