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Long-term contraception with Depo-Provera: a clinical evaluation.
International Journal of Fertility
|January 1, 1980
Summary
Depo-Provera (medroxyprogesterone acetate) is an injectable contraceptive. While some women experience menstrual issues, long-term use leads to amenorrhea and few major side effects, comparable to oral contraceptives.
Area of Science:
- Reproductive Health
- Endocrinology
- Pharmacology
Background:
- Depo-Provera, a depot formulation of medroxyprogesterone acetate (DMPA), is a widely used long-acting injectable contraceptive.
- Understanding its long-term efficacy and side effect profile in diverse populations is crucial for informed clinical practice.
Purpose of the Study:
- To evaluate the acceptability and side effect profile of DMPA (Depo-Provera) administered at 150 mg every 90 days in women in India.
- To assess changes in menstrual bleeding patterns and other adverse events with prolonged use.
Main Methods:
- A longitudinal study was conducted over more than two years.
- Participants received DMPA injections at 90-day intervals.
- Menstrual bleeding patterns, weight changes, and adverse reactions were monitored.
Main Results:
- DMPA was found to be acceptable to some women, despite initial menstrual problems.
- Irregular or excessive menstrual bleeding decreased with continued use, and a high percentage of users achieved amenorrhea.
- No major adverse reactions were observed; minor side effects were comparable to oral contraceptives.
- A tendency for weight gain was noted, and endometrial atrophy was observed with prolonged therapy.
Conclusions:
- DMPA (Depo-Provera) is a viable long-acting injectable contraceptive option for women in this region of India.
- While initial menstrual irregularities are common, they tend to resolve with sustained use, leading to amenorrhea.
- The safety profile is favorable, with side effects generally mild and comparable to oral contraceptives, though weight gain and endometrial changes warrant consideration.