Modulation of motor activity by alpha 1- and alpha 2-adrenoceptor stimulation in mice

The influence of two alpha-adrenoceptor agonists, clonidine and B-HT 920, on motor activity was tested in mice. Both, clonidine and B-HT 920 (2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo-[4,5-d]-azepine) in the dose range 30--300 micrograms/kg s.c. effectively inhibited exploratory activity. On the other hand only clonidine, which stimulates alpha 2- and alpha 1-adrenoceptors increased locomotor activity in mice treated with reserpine (5 mg/kg) and apomorphine (3 mg/kg) in the doses of 0.3 and 1 mg/kg i.p. The highly selective alpha 2-agonist B-HT 920 was ineffective under these conditions up to 30 mg/kg i.p. It is concluded, that in mice "sedative" alpha-adrenoceptors are of the alpha 2- and "excitatory" of the alpha 1-type.