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[Vascular functional disorders in insulin-dependent diabetes]
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|October 1, 1981
Summary
Diabetic patients show reduced artery elasticity and altered blood flow regulation in lower limbs, indicating autonomous neuropathy. These vascular changes are linked to metabolic and hormonal factors during exercise.
Area of Science:
- Vascular Medicine
- Diabetology
- Neurology
Context:
- Diabetes mellitus of juvenile onset type affects vascular function.
- Peripheral macroangiopathy was absent in study participants.
- Angiological measurements were taken at rest and during exercise.
Purpose:
- To objectify vascular function disturbances in juvenile diabetes.
- To assess lower extremity vascular responses to exercise.
- To correlate vascular changes with microangiopathy and influencing factors.
Summary:
- Patients with diabetes exhibited shorter pulse wave times, suggesting decreased arterial elasticity compared to healthy individuals.
- Rheographic and Doppler sonographic parameters indicated prolonged muscular arteriole dilation post-exercise.
- No significant correlation was found between these vascular changes and the severity of retinopathy.
Impact:
- Vascular hemodynamic vasomotor dysfunction in diabetes is primarily a sign of autonomic neuropathy.
- Altered blood supply regulation during exercise involves adrenergic beta-2 receptor stimulation and metabolic factors.
- Findings highlight the complex interplay of metabolic, hormonal, and neural factors in diabetic vascular complications.