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Updated: Aug 19, 2026

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High-Resolution 3D Imaging of Rabies Virus Infection in Solvent-Cleared Brain Tissue
Published on: April 30, 2019
Properties of rabies vaccine freed of neuroallergenic factor from brain tissue
Acta Virologica
|September 1, 1981
Abstract:
Fixed rabies virus in the form of infected sheep brain suspension was freed from approx. 80% of ballast proteins, inactivated by beta-propiolactone and lyophilized. The vaccine thus obtained was devoid of neuroallergenicity when tested on guinea pigs and was highly antigenic and immunogenic. The vaccine caused no generalized reactions in volunteers; local reactions were weak and of short duration. Antibody formation was intensive in all volunteers.

