Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lorazepam in intensive care.

P J Simpson, R J Eltringham

    Clinical Therapeutics
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Lorazepam effectively sedates critically ill patients in intensive care, offering predictable effects. Its suitability is compared to diazepam, considering potential accumulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Heterogenous malignant presacral teratoma with a locally destructive benign intrasacral component.

    Techniques in coloproctology·2013
    Same author

    Evaluation of oxygen concentrators for use in countries with limited resources.

    Anaesthesia·2013
    Same author

    What are the issues in organ donation in 2012?

    British journal of anaesthesia·2011
    Same author

    Defect studies of ZnSe nanowires.

    Nanotechnology·2011
    Same author

    Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells.

    Oncogene·2009
    Same author

    The Glostavent: evolution of an anaesthetic machine for developing countries.

    Anaesthesia and intensive care·2008
    Same journal

    Reimagining Representation Across the Clinical Research Ecosystem: Part II of a Specialty Update on Advancing Diversity, Racial Equity, and Inclusion in Clinical Research.

    Clinical therapeutics·2026
    Same journal

    Combined Effects of Nicorandil and Enhanced External Counterpulsation on Coronary Microcirculation and Exercise Capacity in Patients With Coronary Slow Flow Phenomenon: A Randomized, Controlled, 3-Arm Trial.

    Clinical therapeutics·2026
    Same journal

    Phase 1 Study Evaluating Gefurulimab Pharmacokinetics and Safety Following Delivery Via Autoinjector or Prefilled Syringe With Needle Safety Device in Healthy Adults.

    Clinical therapeutics·2026
    Same journal

    Evaluating Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Associated With Newer Antiseizure Medications Using FAERS and JADER Combined With Bioinformatics Exploration.

    Clinical therapeutics·2026
    Same journal

    Diversity: A Medical Research Imperative.

    Clinical therapeutics·2026
    Same journal

    LOARGYS (pegzilarginase-nbln).

    Clinical therapeutics·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Critical Care Medicine
    • Intensive Care Unit (ICU) Sedation

    Background:

    • Sedation is crucial for managing critically ill patients in the ICU.
    • Lorazepam is a benzodiazepine with potential sedative properties for intensive care.

    Purpose of the Study:

    • To evaluate the suitability and efficacy of lorazepam as a sedative in severely ill ICU patients.
    • To compare lorazepam with diazepam for ICU sedation, considering drug accumulation and clinical benefits.

    Main Methods:

    • A critical evaluation of lorazepam's suitability in 36 severely ill patients.
    • Assessment of cardiovascular and neurological status, alongside nursing staff observations.
    • Administration of lorazepam during both mechanical ventilation and spontaneous breathing.

    Related Experiment Videos

    Main Results:

    • Lorazepam provided predictable and even sedation.
    • The drug was administered to diverse patient groups requiring intensive care.
    • Potential for lorazepam accumulation was investigated and compared to diazepam.

    Conclusions:

    • Lorazepam demonstrates suitability as an ICU sedative, offering predictable and even sedation.
    • The long-acting nature of lorazepam presents potential benefits in intensive care settings.
    • Further comparison with diazepam is warranted, particularly regarding accumulation and clinical advantages.