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Related Experiment Videos

Quinidine in falciparum malaria.

N J White, S Looareesuwan, D A Warrell

    Lancet (London, England)
    |November 14, 1981
    PubMed
    Summary

    Oral quinidine effectively treated Plasmodium falciparum malaria in fourteen patients, showing no cardiotoxicity. This antimalarial drug may be more potent than quinine, with lower minimum inhibitory concentrations observed in vitro.

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    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Tropical Medicine

    Background:

    • Plasmodium falciparum malaria remains a significant global health threat.
    • Drug resistance necessitates the development of novel and effective antimalarial treatments.
    • Quinine has been a primary treatment, but its efficacy is challenged by resistance and side effects.

    Purpose of the Study:

    • To evaluate the efficacy and safety of oral quinidine for treating Plasmodium falciparum malaria.
    • To compare the in vitro activity of quinidine and quinine against Plasmodium falciparum.

    Main Methods:

    • A clinical study treated fourteen patients with oral quinidine.
    • Patient follow-up assessed recrudescence for 35 days.
    • In vitro cultures compared minimum inhibitory concentrations (MICs) of quinidine and quinine.

    Main Results:

    • All fourteen patients achieved successful treatment with oral quinidine.
    • Twelve patients remained free of recrudescence for 35 days.
    • In vitro studies demonstrated consistently lower MICs for quinidine compared to quinine.

    Conclusions:

    • Oral quinidine is an effective treatment for Plasmodium falciparum malaria.
    • Quinidine shows potential for greater potency than quinine against this parasite.
    • Further investigation into quinidine's role in malaria treatment is warranted.

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