Multi-vacuolated leydig cells in human adult cryptorchid testes

A histological study of 23 testicular biopsies or surgical specimens from adult cryptorchid testes revealed the presence of multi-vacuolated Leydig cells in 12 cases. These cells showed abundant lipid inclusions and scarce secondary lysosomes as well as liprofuchsin pigment granules. Some of these cells contained crystals of Reinke but others had only microcristalline inclusions. This Leydig cell alteration may be related either to heat or to congenital lesions.