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Related Experiment Videos

Interaction between ethanol and antihistamines: 3. mebhydrolin.

H M Franks, M Lawrie, V V Schabinsky

    The Medical Journal of Australia
    |October 31, 1981
    PubMed
    Summary

    Mebhydrolin alone did not affect performance, but it worsened ethanol-induced deficits in student volunteers. The drug also showed antihistaminic effects during the study.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Human Physiology

    Background:

    • Mebhydrolin is an antihistamine.
    • Ethanol is known to impair cognitive and motor functions.

    Purpose of the Study:

    • To investigate the effects of mebhydrolin, alone and with ethanol, on human performance.
    • To assess mebhydrolin's antihistaminic activity during ethanol interaction.

    Main Methods:

    • 17 student volunteers participated in the study.
    • Oral administration of mebhydrolin (0.71 mg/kg) and ethanol (0.75 g/kg).
    • Evaluation of perceptual, cognitive, and motor functions, along with histamine challenge tests.

    Main Results:

    • Mebhydrolin alone did not significantly alter performance.
    • Mebhydrolin enhanced performance deficits induced by ethanol.
    • The mebhydrolin dose exhibited antihistaminic effects during the ethanol interaction period.

    Conclusions:

    • Mebhydrolin may potentiate ethanol's impairing effects on cognitive and motor functions.
    • The antihistaminic property of mebhydrolin was confirmed.
    • Further research is needed to understand the implications of this interaction.

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