6 -Hydroxydopamine decreases benzodiazepine but not GABA receptor binding in rat cerebellum

The noradrenergic innervation to the cerebellum was lesioned by intracerebroventricular 6-hydroxydopamine and the effects on GABA and benzodiazepine receptors followed by radiolabelling experiments. This lesion produced a 20% decrease in benzodiazepine receptor labelling in the cerebellum with no change in the labelling of GABA receptors. This provides further evidence for a lack of identity between the GABA and benzodiazepine receptors.