The use of indapamide in resistant hypertensive therapy

For this study hypertensive patients were selected who were taking at least a diuretic, a beta-blocker and a vasodilator. The diuretic was replaced by indapamide 2.5 mg daily. The objective was to assess the effect on blood pressure control and if possible reduce the total dose of the drugs administered, and also the side effects. 25 patients were admitted to the study. Four withdrew because of side effects. Of the remainder, blood pressure control improved in 10 patients, and in 7, some of the concomitant therapy was either withdrawn or reduced. Transient hypokalaemia developed in one patient byt the patient recovered without therapy. There was no significant increase in either serum uric acid or blood glucose.