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Stimulated lymphocytes in schizophrenia.
Neuroleptic medication may reduce P-type atypical lymphocytes in schizophrenia patients. These P cells, a distinct lymphocyte type, were present in all patients studied, but at lower levels in those on medication.
Area of Science:
- Immunology
- Psychiatry
- Cell Biology
Background:
- Atypical lymphocytes, specifically P-type atypical lymphocytes, are observed in schizophrenia.
- P cells exhibit distinct morphological features including cytoplasmic basophilia and irregular nuclear structure.
Purpose of the Study:
- To investigate the effect of neuroleptic medication on the prevalence of P-type atypical lymphocytes in schizophrenia patients.
- To determine if neuroleptic treatment influences the observed P-cell distribution.
Main Methods:
- Analysis of lymphocyte distribution in 42 schizophrenia patients.
- Characterization of P-type atypical lymphocytes based on morphological criteria.
- Comparison of P-cell percentages between patients on neuroleptic medication and those not receiving it.
Main Results:
- P-type atypical lymphocytes were identified in all 42 schizophrenia patients, constituting 5% to 45% of lymphocytes.
- Patients receiving neuroleptic medication showed a lower mean percentage of P cells (17.8%) compared to untreated patients (28.7%).
Conclusions:
- Neuroleptic medication is unlikely to induce the P-cell reaction observed in schizophrenia.
- The study suggests a potential modulatory effect of neuroleptics on P-cell distribution in schizophrenia.
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