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Related Experiment Videos

Hyperprolactinaemia in men-response to bromocriptine therapy.

R W Prescott, D G Johnston, P Kendall-Taylor

    Lancet (London, England)
    |January 30, 1982
    PubMed
    Summary

    Bromocriptine effectively treats hyperprolactinaemia in men with large prolactinomas. This therapy improved symptoms, normalized prolactin levels, and reduced tumor size, suggesting it as a preferred treatment option.

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    Area of Science:

    • Endocrinology
    • Oncology

    Background:

    • Hyperprolactinaemia in men often presents with large pituitary tumors.
    • Conventional treatments like surgery and irradiation have limited success and can cause pituitary insufficiency.

    Purpose of the Study:

    • To evaluate bromocriptine as a primary therapy for male hyperprolactinaemia with large tumors.
    • To assess bromocriptine's efficacy in improving hormonal imbalances and reducing tumor size.

    Main Methods:

    • Eight male patients with hyperprolactinaemia and large tumors received bromocriptine (20 mg daily) as sole therapy for 3-11 months.
    • Evaluated symptomatic relief, serum prolactin, pituitary hormone responses, and tumor size via radiology.

    Main Results:

    • Seven of eight patients experienced partial or complete symptom relief.

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  • All patients normalized or near-normalized serum prolactin levels.
  • Tumor regression was observed in six patients, with significant improvements in hormonal function and testosterone levels.

    • Conclusions:

    • Bromocriptine monotherapy is highly effective for male hyperprolactinaemia with large tumors.
    • It offers symptomatic, biochemical, and radiological improvements, potentially making it the treatment of choice.
    • This approach avoids the complications associated with surgery and irradiation.