Noradrenaline and alpha blockers in daunomycin cardiotoxicity

The total tissue noradrenaline content of the heart from daunomycin acutely treated guinea pigs has been found to be significantly increased compared with controls. Under the same treatment, electrocardiograms showed the occurrence of alterations of electrical waves, consisting of a decrease and reversion of T waves, or an increase in their voltage. Pretreatment with alpha blocking drugs nicergoline and yohimbine failed to protect the animals from daunomycin cardiotoxicity.