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Multiple compression of powders in a tablet press
The Journal of Pharmacy and Pharmacology
|January 1, 1982
Summary
Repeated tablet compression initially reduces force due to lower porosity structures. However, with increased intervals, this force reduction lessens, with some materials showing greater force on second compression.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Tablet hardness and mechanical properties are crucial for drug delivery.
- Understanding the impact of compression cycles on compact properties is essential for optimizing tablet manufacturing.
Purpose of the Study:
- To investigate the effect of repeated compression on the mechanical properties of various pharmaceutical excipients.
- To analyze the influence of compression interval on tablet force and porosity.
Main Methods:
- Multiple compression cycles were applied to lactose, magnesium carbonate, phenacetin, microcrystalline cellulose, and directly compressible starch compacts without ejection.
- Compression force and intervals were systematically varied.
Main Results:
- At a 1.3s interval, all substances exhibited decreased maximum compression force, indicating structural changes and reduced porosity.
- Increasing the interval between compressions diminished the observed force decrease.
- Microcrystalline cellulose and directly compressible starch showed increased force on the second compression compared to the first.
Conclusions:
- The study demonstrates that repeated compression influences tablet mechanical properties and porosity.
- Compression interval is a critical parameter affecting the outcome of multiple compression events in tableting.