The mobilization of plasma lipids by histamine in dogs

The aim of the present work was to study the mechanism of the mobilization of plasma lipids produced by histamine in the dog, in vivo. The increase of plasma lipids by histamine in vivo was suppressed by cimetidine, but not by diphenhydramine. Although, histamine increased the level of plasma adrenaline, adrenaline does not appear to contribute to the lipolysis stimulated by histamine, because propranolol and alprenolol, beta-adrenergic blocking agents, did not affect the lipolysis stimulated by histamine. From these data it is concluded that the increase of plasma lipids in vivo is not attributable to the release of adrenaline from adrenal glands by histamine, but is produced by the stimulation through H2-receptors in fat cells.