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Assessment of left-ventricular mass and its response to antihypertensive treatment

D B Rowlands, D R Glover, M A Ireland

    Lancet (London, England)
    |February 27, 1982
    PubMed

    Insights

    Essential hypertension significantly correlates with left-ventricular (LV) mass. Antihypertensive therapy effectively reduces both blood pressure and LV mass in patients with hypertension.

    Area of Science:

    • Cardiology
    • Hypertension Research
    • Diagnostic Imaging

    Background:

    • Essential hypertension is a common condition associated with cardiovascular complications.
    • Left-ventricular (LV) hypertrophy is a significant predictor of cardiovascular events in hypertensive patients.
    • Echocardiography is a key tool for assessing cardiac structure and function.

    Purpose of the Study:

    • To investigate the relationship between blood pressure and left-ventricular mass in patients with essential hypertension.
    • To evaluate the effect of antihypertensive therapy on blood pressure and LV mass.

    Main Methods:

    • M-mode echocardiography and continuous intra-arterial ambulatory blood pressure monitoring were used.
    • Left-ventricular mass indices were calculated from echocardiographic data.
    • Patients were followed up with repeat echocardiography and blood pressure measurements.

    Main Results:

    • Mean 24-hour systolic blood pressure showed a significant correlation with echocardiographic LV mass.
    • Antihypertensive therapy led to significant reductions in both blood pressure and LV mass index compared to untreated patients.
    • A strong correlation was observed between the reduction in systolic blood pressure and LV mass index in the treated group.

    Conclusions:

    • Systolic blood pressure plays a crucial role in the pathogenesis of left-ventricular hypertrophy.
    • Echocardiographically assessed changes in LV mass correlate with blood pressure changes in hypertensive individuals.
    • Antihypertensive treatment can reverse cardiac structural changes associated with hypertension.

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