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Rat lymphoid leukemia of T cell type induced by 7,12-dimethylbenz(alpha)anthracene. Immunological and enzymological
Oncology
|January 1, 1982
Abstract:
Lymphoid leukemia induced by 7,12-dimethylbenz(alpha)anthracene (DMBA) in rats and maintained by serial intraperitoneal transplantations in newborn rats was subjected to immunological and enzymological characterization. The Thy-1 antigen positivity rendered evidence for the T cell origin of the leukemia studied. Expression of cell surface complement binding receptors and patterns of cytoplasmic acid phosphatase and nonspecific acid alpha-naphthyl acetate esterase enzymes drew the attention to the dominance of lymphoblasts and prolymphocytes.