[Predicting the effect of psychopharmacotherapy in schizophrenic patients]

For forecasting the immediate effect of neuroleptic and insulin-shock therapy of schizophrenic patients (240 observations, as a total) modified rating scales are offered which enable one to forecast more precisely the immediate effect of those treatment forms. The response to a single dose of a neuroleptic (aminazine, haloperidol, triftazin) given before the treatment start and the effects of the same drugs obtained as a result of the treatment with them were compared (in 180 schizophrenics). The comparison has shown that it was marked emotional changes which were the most favourable prognostically (alleviation of negative emotions). The connection between the therapy effect and the motor changes was less distinct. Vegetative reactions were found to be the least informative. Pronounced reactions of that type more often correlated with good results of the treatment. In therapy-resistant patients, such reactions were absent.