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Lorazepam premedication for labour.

D M McAuley, M P O'Neill, J Moore

    British Journal of Obstetrics and Gynaecology
    |February 1, 1982
    PubMed
    Summary
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    Lorazepam supplementation during labor significantly improved pain relief and patient satisfaction compared to placebo. However, it was associated with a higher incidence of infant respiratory depression and maternal amnesia.

    Area of Science:

    • Obstetrics
    • Pharmacology
    • Anesthesiology

    Background:

    • Pethidine is commonly used for labor analgesia.
    • Adjunctive medications are sometimes used to enhance pain relief.
    • The effects of lorazepam as a labor analgesic supplement require investigation.

    Purpose of the Study:

    • To evaluate the efficacy and safety of lorazepam as an adjunct to pethidine for labor analgesia.
    • To compare patient satisfaction with analgesic regimens.

    Main Methods:

    • A randomized, double-blind, placebo-controlled study involving 50 primigravidae in early labor.
    • Participants received either 2 mg lorazepam or placebo tablets.
    • Pethidine (100 mg) was administered as needed, with pain assessed via visual analogue scale.

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    Main Results:

    • Significantly better analgesia was observed in the lorazepam group.
    • Higher patient satisfaction was reported in the lorazepam group.
    • Increased incidence of infant respiratory depression and maternal amnesia was noted in the lorazepam group, though not statistically significant.

    Conclusions:

    • Lorazepam appears to enhance pethidine's analgesic effect and improve patient satisfaction during labor.
    • Potential risks, including neonatal respiratory depression and maternal amnesia, warrant further investigation.
    • Further studies on other adjuncts to pethidine analgesia are needed.