Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Peripheral nerve repair.

K Kristensson, T Olsson

International Rehabilitation Medicine

|January 1, 1981

Summary

This summary is machine-generated.

Axotomy, or nerve injury, disrupts axonal transport in neurons. This transport resumes after nerve repair and reinnervation, potentially signaling neuronal recovery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Trace elements in the human central nervous system studied with neutron activation analysis.

Biological trace element research·2013

Same author

A simple histochemical method for double labelling of neurons by retrograde axonal transport.

Neuroscience letters·2009

Same author

Differential invasion of Trypanosoma brucei brucei and lymphocytes into the brain of C57BL/6 and 129Sv/Ev mice.

Scandinavian journal of immunology·2008

Same author

NK cell-mediated destruction of influenza A virus-infected peripheral but not central neurones.

Scandinavian journal of immunology·2007

Same author

Interferon-gamma mediates neuronal killing of intracellular bacteria.

Scandinavian journal of immunology·2004

Same author

Activation of natural killer cells: underlying molecular mechanisms revealed.

Scandinavian journal of immunology·2004

Same journal

Retraining of functional gait through the reduction of upper extremity weight-bearing in chronic cerebellar ataxia.

International rehabilitation medicine·1987

Same journal

Functional impairment of the sacroiliac joint after total hip replacement.

International rehabilitation medicine·1987

Same journal

Prevalence of motor impairment and disability in a rural community in KwaZulu.

International rehabilitation medicine·1987

Same journal

Such sweet sorrow.

International rehabilitation medicine·1987

Same journal

Vocational rehabilitation.

International rehabilitation medicine·1987

Same journal

Epidemiology of some neurological diseases with special reference to work load on the NHS.

International rehabilitation medicine·1987

See all related articles

Area of Science:

Neuroscience
Cell Biology
Neurobiology

Background:

Neurons possess a long projection, the axon, crucial for cellular transport.
Axonal transport is vital for neuron function and survival.
Axotomy (nerve injury) significantly disrupts axonal transport dynamics.

Purpose of the Study:

To investigate the impact of axotomy on somatopetal axonal transport.
To understand the recovery patterns of axonal transport following nerve injury and reinnervation.

Main Methods:

Utilized tracer macromolecules to study somatopetal axonal transport.
Employed the mouse facial neuron model to observe transport dynamics.
Monitored transport blockage and resumption post-axotomy and reinnervation.

Related Experiment Videos

Main Results:

Axotomy initially blocked axonal transport from muscle terminals.
Transport persisted at the injured axonal membrane until it sealed.
Axonal transport resumed after successful reinnervation of the distal stump.

Conclusions:

Axonal transport is profoundly affected by axotomy but recovers post-reinnervation.
Resumed transport may play a role in signaling neuronal responses to injury.
Understanding these transport dynamics is key to nerve regeneration research.