Effects of beta-adrenergic agents on the murine lymphocyte response to mitogen stimulation

The presence of beta-adrenergic receptors on murine lymphocytes has recently been demonstrated (8). beta-adrenergic agonists and antagonists have been found to alter the murine lymphocyte's response to either Concanavalin A or Lipopolysaccharide B. The regulation of the response to Concanavalin A or Lipopolysaccharide B by these beta-adrenergic ligands is most effective if the beta-adrenergic ligand is added within one hour of the addition of mitogen and at concentrations greater than 1 x 10(-7) M. The possibility that adrenergic modulation of the lymphocyte response may be beta-receptor mediated is supported by the observation of competition between adrenergic agonists and antagonists.