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Electrostatic charge interactions in ordered powder mixes.

J N Staniforth, J E Rees

    The Journal of Pharmacy and Pharmacology
    |February 1, 1982
    PubMed
    Summary
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    This study introduces a method to measure powder electrostatic charge, finding that surface contact and triboelectrification significantly impact charge levels and the stability of ordered powder mixes, with oppositely charged particles forming more stable mixtures.

    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science
    • Electrostatics

    Background:

    • Electrostatic charging of powders is critical in pharmaceutical manufacturing.
    • Understanding charge generation is key to controlling powder behavior and mix stability.

    Purpose of the Study:

    • To develop and validate a method for measuring specific powder electrostatic charge.
    • To investigate the influence of surface interactions and triboelectrification on powder charging.
    • To assess the impact of electrostatic charge on the stability of ordered powder mixes.

    Main Methods:

    • Utilized a Faraday well connected to an electrometer to quantify powder electrostatic charge.
    • Examined charge generation upon contact with different substrates (glass, polyethylene).

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  • Investigated triboelectrification using an air cyclone and analyzed ordered mix stability.

    • Main Results:

    • Powders exhibited surface-dependent charging (negative on glass, positive on polyethylene).
    • Oppositely charged drug and excipient particles formed more stable ordered mixes than like-charged particles.
    • Triboelectrification generated charges over 100 times greater than surface contact.
    • Optimized triboelectrification created ordered mixes with maximized opposite charges on drug and excipient.

    Conclusions:

    • The developed method accurately measures specific powder charge.
    • Electrostatic interactions significantly influence ordered mix stability and segregation.
    • Triboelectrification offers a powerful method for controlling powder charge and enhancing mix stability.