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Interparticle forces in binary and ternary ordered powder mixes.

J N Staniforth, J E Rees, F K Lai

    The Journal of Pharmacy and Pharmacology
    |March 1, 1982
    PubMed
    Summary
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    Investigating pharmaceutical powder adhesion, this study found that increasing carrier excipient particle size enhances drug powder adhesion in binary mixes. Ternary mix stability depends on carrier properties and charge interactions.

    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science
    • Physical Chemistry

    Background:

    • Ordered powder mixes are crucial in pharmaceutical formulations.
    • Understanding powder adhesion is key to predicting formulation stability and performance.
    • Previous ultracentrifuge methods provide a basis for studying powder interactions.

    Purpose of the Study:

    • To investigate the adhesion profiles of binary and ternary ordered powder mixes using ultracentrifugation.
    • To determine the influence of carrier excipient particle size on drug-excipient adhesion.
    • To examine how adding a third excipient affects the adhesion profile and stability of binary ordered mixes.

    Main Methods:

    • Utilized an established ultracentrifuge technique to analyze powder adhesion.

    Related Experiment Videos

  • Prepared and analyzed binary ordered mixes of drug powders and carrier excipients.
  • Formed ternary ordered mixes by adding fine powders to binary systems and assessed their stability.

    • Main Results:

    • Excipient particle size significantly impacts adhesion in binary ordered mixes; larger recrystallized lactose particles improved drug powder adhesion.
    • Ternary ordered mix adhesion profiles were altered by the addition of fine powders.
    • Physical properties of carrier particles and charge interactions were identified as critical factors influencing ternary mix stability.

    Conclusions:

    • Carrier particle size is a critical parameter for optimizing drug-excipient adhesion in binary ordered pharmaceutical powder mixes.
    • Ternary ordered mix stability is influenced by a complex interplay of particle size, physical properties, and inter-particulate charge interactions.
    • The ultracentrifuge technique effectively characterizes adhesion profiles, providing insights into the physical stability of pharmaceutical powder systems.