Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scleroderma and intestinal perforation.

P T Regan, L H Weiland, M G Geall

    The American Journal of Gastroenterology
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risk and significance of endoscopic/radiological evidence of recurrent Crohn's disease.

    Gastroenterology·1997
    Same author

    Malignant fibrous histiocytoma of the lung. Report of four cases and review of the literature.

    Cancer·1996
    Same author

    Salivary duct carcinoma. Clinicopathologic and immunohistochemical review of 26 cases.

    Cancer·1996
    Same author

    Trends in colorectal cancer over a half century in Rochester, Minnesota, 1940 to 1989.

    Annals of epidemiology·1995
    Same author

    Mucous membrane plasmacytosis of the upper aerodigestive tract. A clinicopathologic study.

    The American journal of surgical pathology·1994
    Same author

    Pediatric surgical pathology of the head and neck.

    Seminars in pediatric surgery·1994
    Same journal

    ACG Clinical Guideline: Colonic Diverticulitis.

    The American journal of gastroenterology·2026
    Same journal

    Inter and intra-observer agreement for the LST Classification in Large (>2cm) Colorectal Laterally Spreading Tumours.

    The American journal of gastroenterology·2026
    Same journal

    The Safety and Effectiveness of Early Anti-Tumor-Necrosis-Factor Therapy for Penetrating Crohn's Disease Complications in Children.

    The American journal of gastroenterology·2026
    Same journal

    Continuing Medical Education Questions: September 2024.

    The American journal of gastroenterology·2026
    Same journal

    Continuing Medical Education Questions: September 2024.

    The American journal of gastroenterology·2026
    Same journal

    Continuing Medical Education Questions: September 2024.

    The American journal of gastroenterology·2026
    See all related articles

    Scleroderma can cause intestinal perforation, including colonic perforations linked to fecal impaction or vasculitis. Rare cases of spontaneous small intestine perforation also occur in scleroderma patients.

    Area of Science:

    • Gastroenterology
    • Rheumatology
    • Pathology

    Background:

    • Scleroderma is a systemic autoimmune disease characterized by fibrosis and vascular abnormalities.
    • Intestinal complications are a known manifestation of scleroderma, impacting motility and integrity.
    • Gastrointestinal involvement significantly affects patient morbidity and mortality.

    Observation:

    • Four cases of intestinal perforation in patients with scleroderma were reviewed.
    • Three cases involved colonic perforation, with two linked to fecal impaction and stercoral ulceration.
    • One colonic perforation showed evidence of underlying vasculitis.

    Findings:

    • The study identified a strong association between scleroderma and intestinal perforation.
    • Fecal impaction, stercoral ulceration, and vasculitis are potential contributing factors to colonic perforation in scleroderma.

    Related Experiment Videos

  • A rare instance of spontaneous small intestine perforation was also documented.

    • Implications:

    • These findings highlight the critical need for vigilant monitoring of gastrointestinal complications in scleroderma patients.
    • Early recognition and management of fecal impaction and vasculitis may help prevent intestinal perforation.
    • Further research is warranted to elucidate the precise mechanisms linking scleroderma to intestinal perforation.