Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peptidergic nerves.

A E Bishop, G L Ferri, L Probert

    Scandinavian Journal of Gastroenterology. Supplement
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.

    Oncogene·2024
    Same author

    A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.

    Oncogene·2016
    Same author

    Temperature-driven nonclassical light.

    Physical review. E, Statistical, nonlinear, and soft matter physics·2013
    Same author

    Differential expression of enteric neuroimmune-network in invasive and acute watery diarrhoea.

    Neurogastroenterology and motility·2009
    Same author

    In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived peptide, in the regulation of rat gastric motor functions.

    British journal of pharmacology·2009
    Same author

    Biocompatibility of poly-DL-lactic acid (PDLLA) for lung tissue engineering.

    Journal of biomaterials applications·2006

    The autonomic nervous system, particularly in the gut, is more complex than previously thought, featuring a sophisticated network of peptide-containing nerves. This "minibrain" system, while influenced by the central nervous system, can function autonomously, and its dysfunction is linked to gut diseases.

    Area of Science:

    • Neuroscience
    • Gastroenterology
    • Cell Biology

    Background:

    • The autonomic nervous system (ANS) is more complex than initially understood, containing diverse neurotransmitter substances.
    • A significant portion of the ANS, especially within the gastrointestinal tract, comprises peptide-containing nerves, forming an intricate network throughout the gut.

    Purpose of the Study:

    • To investigate the complexity and distribution of the peptidergic nervous system within the gut.
    • To understand the functional implications of this intrinsic enteric nervous system.

    Main Methods:

    • Utilized specialized immunocytochemical methods to study the distribution and morphology of peptidergic nerves.
    • Correlated the distribution of these nerves with the known actions of individual peptides.

    Related Experiment Videos

    Main Results:

    • Identified a major complex of peptidergic nerves infiltrating the entire length of the gastrointestinal tract.
    • Demonstrated that the majority of these peptidergic nerves are intrinsic to the gut, forming a largely autonomous unit.
    • Observed that the distribution patterns of these nerves often align with the physiological actions of specific peptides.

    Conclusions:

    • The enteric nervous system functions as a
    • minibrain
    • with a degree of autonomy from the central nervous system.
    • Dysfunction within this complex peptidergic system is implicated in various gastrointestinal diseases.