[Effect of adrenomimetic, adreno- and ganglionic-blocking agents during hyperbaric oxygenation]

Experiments on rats were made to study the action of hypotension and vasopressive agents. The effects obtained as a result of administering the drugs under common gas medium and hyperbaric oxygenation were compared. A considerable reduction of hypotensive action of alpha- and beta-adrenoblockers, ganglioblockers, beta-adrenomimetics and elimination of the effect of central alpha-adrenomimetics were discovered. The pressor effects of direct- and particularly of indirect-action alpha-adrenomimetics, as well as cardiotropic effects of beta-adrenoblockers were found to be potentiated. It is suggested that the action mode of oxygen is mediated via its direct- and primarily indirect-action adrenomimetic and beta-adrenoblocking effects. A classification of the periods of combined action of the drugs and hyperbaric oxygenation is suggested.