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[Exocrine pancreas function - does it change with age? (author's transl)].

J Mössner, H J Pusch, W Koch

    Aktuelle Gerontologie
    |March 1, 1982
    PubMed
    Summary
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    Pancreatic function declines with age. Older adults show reduced secretion of key enzymes like lipase and amylase compared to younger individuals, indicating age-related pancreatic fatigue.

    Area of Science:

    • Gastroenterology
    • Pancreatology
    • Aging Research

    Background:

    • Pancreatic function is crucial for digestion.
    • Age-related changes in organ function are common, but specific impacts on the pancreas require detailed study.

    Purpose of the Study:

    • To compare the excretory pancreatic function between healthy young and older adult populations.
    • To investigate age-related differences in pancreatic enzyme secretion and response to stimulation.

    Main Methods:

    • Utilized a modified secretin-pancreozymin test for pancreatic function assessment.
    • Administered sequential infusions of secretin and pancreozymin to measure enzyme output.
    • Compared results between a young cohort (mean age 31.8) and an older cohort (mean age 58.7).

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    Main Results:

    • Older adults exhibited significantly lower secretion rates for bicarbonate, lipase, and amylase compared to younger adults.
    • Trypsin levels were lower in older individuals after repeat stimulation.
    • Pancreatic fatigue, indicated by reduced trypsin production after a second stimulation, was observed only in the older group.

    Conclusions:

    • Healthy aging is associated with diminished excretory pancreatic function.
    • Reduced pancreatic enzyme secretion and the onset of pancreatic fatigue are characteristic of older age groups.