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Related Experiment Videos

Detection of glomerular bleeding by phase-contrast microscopy.

R G Fassett, B A Horgan, T H Mathew

    Lancet (London, England)
    |June 26, 1982
    PubMed
    Summary

    Phase-contrast microscopy of urine red blood cell morphology helps predict the source of haematuria. This method, alongside detecting red blood cell casts and protein, aids clinicians in diagnosing urinary tract conditions.

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    Area of Science:

    • Nephrology
    • Urology
    • Diagnostic Pathology

    Background:

    • Hematuria, or blood in the urine, can originate from various parts of the urinary tract.
    • Differentiating glomerular from non-glomerular sources is crucial for appropriate diagnosis and management.
    • Urinary red blood cell morphology offers potential clues to the source of hematuria.

    Purpose of the Study:

    • To evaluate the utility of phase-contrast microscopy in determining the origin of hematuria based on red blood cell morphology.
    • To correlate urinary red blood cell morphology with specific diagnoses in patients presenting with hematuria.

    Main Methods:

    • Phase-contrast microscopy was used to examine midstream urine specimens from 303 patients with hematuria.
    • Red blood cell morphology was analyzed to classify the origin as glomerular or non-glomerular.
    • Clinical data and diagnostic outcomes were correlated with microscopic findings.

    Main Results:

    • Phase-contrast microscopy successfully predicted the origin of hematuria in a significant proportion of patients.
    • Glomerular hematuria was associated with specific red blood cell morphologies, while non-glomerular hematuria showed different patterns.
    • A mixed picture of red blood cell morphologies was observed in conditions like IgA nephropathy and renal calculi.
    • The presence of red blood cell casts and proteinuria further supported the diagnosis of glomerular disease.

    Conclusions:

    • Phase-contrast microscopy of urinary red blood cell morphology is a valuable tool for predicting the source of hematuria.
    • Integrating red blood cell morphology with other urinary findings like casts and protein enhances diagnostic accuracy.
    • This approach assists clinicians in guiding initial investigations for patients with hematuria.

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