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Related Experiment Videos

Acyclovir therapy for acute herpes zoster.

B Bean, C Braun, H H Balfour

    Lancet (London, England)
    |July 17, 1982
    PubMed
    Summary

    Intravenous acyclovir effectively treated acute herpes zoster, reducing pain and speeding skin healing. However, it did not prevent pain recurrence or post-herpetic neuralgia and had side effects.

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    Area of Science:

    • Virology
    • Dermatology
    • Pharmacology

    Background:

    • Herpes zoster (shingles) is a viral infection causing pain and rash.
    • Effective antiviral treatments are crucial for managing acute herpes zoster.
    • Intravenous acyclovir is a potential therapeutic option.

    Purpose of the Study:

    • To evaluate the efficacy and safety of intravenous acyclovir for acute herpes zoster.
    • To compare acyclovir's effects against a placebo in a randomized controlled trial.

    Main Methods:

    • A randomized, placebo-controlled, double-blind trial involving 31 adult participants.
    • Intravenous acyclovir (500 mg/m2 thrice daily for 5 days) was administered.
    • Outcomes included pain, erythema, lesion formation, healing time, viral shedding, and adverse events.

    Main Results:

    • Acyclovir significantly reduced pain, erythema, and new lesion formation.
    • Skin healing was faster in the acyclovir group compared to placebo.
    • Viral shedding duration was shorter (2 days vs. 5 days) with acyclovir.
    • 35% of acyclovir recipients experienced pain recurrence post-treatment.
    • Acyclovir did not prevent post-herpetic neuralgia and caused transient renal function changes.

    Conclusions:

    • Intravenous acyclovir is effective for acute herpes zoster, improving key clinical outcomes.
    • The current regimen may not be optimal, suggesting a need for dose or duration adjustments.
    • Further research into ideal treatment regimens is warranted to balance efficacy and side effects.

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