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[Pindolol in pediatrics. Evaluation of cardiac haemodinamics (author's transl)]

E Antoncecchi, N Mollica, L Ranieri

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |November 1, 1981
    PubMed

    Insights

    This study explored the effects of the beta-blocking agent Pindolol in children, finding significant variations in certain cardiac parameters but not heart rate or blood pressure. The drug demonstrated easy pediatric utilization.

    Area of Science:

    • Pediatric pharmacology
    • Cardiovascular research
    • Clinical drug evaluation

    Context:

    • Limited research exists on beta-blocking agents' effects in pediatric populations.
    • Pindolol (Visken Sandoz), a beta-blocking agent, was studied in children.
    • Previous studies focused primarily on adult responses to beta-blockers.

    Purpose:

    • To investigate the pharmacological effects of a beta-blocking agent (Pindolol) in healthy children.
    • To assess changes in cardiovascular parameters following a 10-day therapeutic cycle of Pindolol.
    • To evaluate the safety and usability of Pindolol for pediatric use.

    Summary:

    • Nineteen healthy children (5-13 years) received Pindolol (250 gamma/kg/day) for 10 days.
    • Significant variations were observed in TD, TT, TT/TET, and QTc intervals.
    • No significant changes were noted in heart rate, TET, SM, QA2, diastolic parameters, or arterial blood pressure.

    Impact:

    • Suggests potential chronotropic and hypotensive effects in pediatric patients with pre-existing cardiac rate or blood pressure alterations.
    • Highlights the easy administration and utilization of Pindolol in pediatric settings.
    • Provides foundational data for further pediatric research on beta-blocking agents.

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