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Gastroesophageal reflux. Pathogenesis, diagnosis, and therapy
Annals of Internal Medicine
|July 1, 1982
Summary
Gastroesophageal reflux disease (GERD) involves factors like gastric contents and lower esophageal sphincter function. This review covers diagnostic tests and current therapies for GERD, aiding clinical decision-making.
Area of Science:
- Gastroenterology
- Digestive Diseases
Background:
- Recent advancements provide new insights into gastroesophageal reflux disease (GERD).
- Key contributing factors to GERD now include gastric contents, mucosal resistance, esophageal acid clearance, gastric emptying, and lower esophageal sphincter (LES) incompetency.
Purpose of the Study:
- To review potential diagnostic tests for reflux.
- To evaluate the diagnostic accuracy of various reflux tests.
- To outline a diagnostic approach for patients with reflux symptoms.
Main Methods:
- Review of potential diagnostic tests for reflux.
- Evaluation of diagnostic accuracy, sensitivity, and specificity of tests.
- Consideration of test availability for generalists and specialists.
- Summary of controlled studies on current GERD therapies.
Main Results:
- Multiple factors contribute to the pathogenesis of GERD.
- Diagnostic tests for reflux vary in accuracy and availability.
- Current therapeutic strategies for GERD are based on controlled studies.
Conclusions:
- A comprehensive diagnostic approach for GERD should consider test performance and accessibility.
- Current therapies for GERD are supported by medical literature evidence.