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A buffering model for calcium-dependent neurotransmitter release.

D A Nachshen, P Drapeau

    Biophysical Journal
    |May 1, 1982
    PubMed
    Summary

    A new model explains how neurotransmitter release steep dependence on external calcium arises from a single intracellular calcium buffer system. This model accounts for release without requiring cooperative calcium binding.

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    Area of Science:

    • Neuroscience
    • Biophysics

    Background:

    • Neurotransmitter release from presynaptic nerve terminals is crucial for synaptic transmission.
    • The release process exhibits a steep dependence on external calcium concentration.
    • Existing models often invoke cooperative calcium binding to explain this steep dependence.

    Purpose of the Study:

    • To propose a simple biophysical model for neurotransmitter release.
    • To explain the steep external calcium dependence of release without cooperative calcium binding.
    • To investigate the role of intracellular calcium buffering in synaptic transmission.

    Main Methods:

    • Development of a simple mathematical model.
    • Assumption of saturable calcium entry and buffering in the presynaptic terminal.
    • Assumption of release being proportional to intracellular calcium concentration.

    Main Results:

    • A single intracellular calcium buffering system can account for the steep external calcium dependence of neurotransmitter release.
    • The model successfully explains the observed relationship without invoking cooperative calcium binding.
    • The model highlights the interplay between calcium dynamics and release probability.

    Conclusions:

    • Intracellular calcium buffering is a key factor in regulating neurotransmitter release.
    • The proposed model offers a parsimonious explanation for calcium-dependent release.
    • This work provides insights into the biophysical mechanisms underlying synaptic plasticity.

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