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Beta-adrenergic blockade and peripheral vascular disease.

D M Ingram, A K House, G H Thompson

The Medical Journal of Australia

|June 12, 1982

Summary

Beta-blocking drugs may worsen peripheral vascular disease. Stopping these medications significantly improved claudication distance and muscle blood flow in patients with peripheral vascular disease.

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Area of Science:

Cardiology
Vascular Medicine
Pharmacology

Background:

Peripheral vascular disease (PVD) frequently co-occurs with hypertension and ischemic heart disease.
Beta-blocking drugs are commonly prescribed for these conditions.
Concerns exist that beta-blockers might exacerbate PVD symptoms.

Purpose of the Study:

To investigate the impact of beta-blocking drugs on peripheral vascular disease.
To assess the effect of beta-blocker withdrawal on PVD indices.

Main Methods:

A study involving 11 patients with PVD on beta-blockers.
Claudication distance and 133Xe clearance for skin and muscle blood flow were measured.
Beta-blocker administration was ceased, with blood pressure managed by alternative means.

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Main Results:

Significant improvement in claudication distance observed after drug withdrawal.
Resting and post-exercise muscle blood flow showed significant enhancement.
Improvements were noted irrespective of whether cardioselective or nonselective beta-blockers were used.

Conclusions:

Beta-blocking agents appear to aggravate peripheral vascular disease.
Withdrawal of beta-blockers leads to improved PVD-related parameters.
It is recommended to avoid beta-blockers in patients diagnosed with peripheral vascular disease.