Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antithymic antibodies in schizophrenic sera.

M Watanabe, T Funahashi, T Suzuki

    Biological Psychiatry
    |June 1, 1982
    PubMed
    Summary

    Schizophrenic patients exhibit significantly higher antithymic activity in their serum compared to healthy controls. This immune system finding may indicate a broader immunological dysfunction in schizophrenia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diversion of the sign of phototaxis in a Chlamydomonas reinhardtii mutant incorporated with retinal and its analogs.

    FEBS letters·1992
    Same author

    Site-directed mutation makes rabbit calcyclin dimer.

    FEBS letters·1992
    Same author

    Subfrontal schwannoma--case report.

    Neurologia medico-chirurgica·1992
    Same author

    [Neurotoxicity of antiepileptic drugs].

    No to shinkei = Brain and nerve·1992
    Same author

    Effect of multiple irradiation with low doses of gamma-rays on morphological transformation and growth ability of human embryo cells in vitro.

    International journal of radiation biology·1992
    Same author

    Leiomyosarcoma of the esophagus: report of a case and preoperative evaluation by CT scan, endoscopic ultrasonography and angiography.

    Gastroenterologia Japonica·1992

    Area of Science:

    • Immunology
    • Neuroscience
    • Psychiatry

    Background:

    • The role of immunological factors in schizophrenia is an area of ongoing research.
    • Previous studies have suggested potential immune system dysregulation in psychiatric disorders.

    Purpose of the Study:

    • To investigate the presence and levels of antithymic activity in the sera of individuals with schizophrenia.
    • To explore the potential relationship between antithymic activity and schizophrenia.

    Main Methods:

    • Sera from schizophrenic patients and normal controls were analyzed for antithymic activity using a cytotoxicity test with C3H mouse thymocytes.
    • Adsorption studies were performed using mouse and human brain and liver homogenates to identify potential antigens involved.

    Main Results:

    Related Experiment Videos

    • Significantly higher antithymic activity was observed in schizophrenic sera (50.3 +/- 27.1) compared to controls (35.3 +/- 19.5) (p < 0.01).
    • Antithymic activity was adsorbed by mouse brain tissue but not human brain or liver, suggesting it's not related to Thy-1 antigen.
    • No correlation was found between antithymic activity and schizophrenia subtypes or psychopathological status (BPRS score).

    Conclusions:

    • Elevated antithymic activity in schizophrenia may stem from a nonspecific dysfunction of the immunological system.
    • The observed activity is unlikely to be antibodies against the Thy-1 antigen.
    • Antithymic activity is not specific to schizophrenia and may be a marker of general immune dysregulation.