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Related Experiment Videos

Bethanechol chloride and the traumatic cord bladder.

J K Light, F B Scott

    The Journal of Urology
    |July 1, 1982
    PubMed
    Summary

    Bethanechol chloride did not improve voiding dysfunction in men with spinal cord injuries. The drug aggravated bladder outlet obstruction and had unpredictable effects, failing to induce detrusor contractions in some patients.

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    Area of Science:

    • Urology
    • Neuroscience
    • Pharmacology

    Background:

    • Neurogenic bladder disease often results from spinal cord injuries.
    • Voiding dysfunction is a common complication in these patients.
    • Pharmacological interventions are explored to manage neurogenic bladder.

    Purpose of the Study:

    • To evaluate the efficacy of bethanechol chloride in improving voiding dysfunction.
    • To assess the drug's impact on bladder pressure, pelvic floor electromyography, and flow rate.
    • To determine the safety and predictability of bethanechol chloride in this patient population.

    Main Methods:

    • Twenty-eight men with neurogenic bladder secondary to spinal cord damage were enrolled.
    • Simultaneous measurements of bladder pressure, pelvic floor EMG, and flow rate were conducted.
    • The effects were assessed in both supine and sitting positions.

    Main Results:

    • Bethanechol chloride failed to improve voiding dysfunction in any position.
    • The drug aggravated functional bladder outlet obstruction.
    • Unpredictable effects were observed, including altered detrusor contraction patterns and failure to induce contractions in some patients.

    Conclusions:

    • Bethanechol chloride is ineffective for treating voiding dysfunction in men with neurogenic bladder due to spinal cord injury.
    • The drug can worsen bladder outlet obstruction and exhibits unpredictable effects.
    • Its use in patients with areflexia or wave pattern bladders is not recommended due to lack of efficacy.

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