[Local tolerance for co-trimoxazole i. m.. Comparison with an intramuscularly administered penicillin combination]

The local tolerance of intramuscular co-trimoxazole and a combination of penicillin-G-sodium, clemizol-penicillin-G and lidocain-hydrochloride (PCPL) was investigated in an open comparative trial in two groups of patients of the ENT-Department of the Medical School Hanover. 15 male and 15 female patients received co-trimoxazole injections and 18 male and 12 female patients PCPL-injections both for three days. The injections were given deep intramuscularly in the morning and evening alternating into the right respectively left exterior quadrant of the gluteal region. Frequency of local disturbances was obviously connected with the period of treatment in both preparations. There was no difference between both preparations as concerns subjective and objective local symptoms. In 90% of the cases of both groups the local tolerance was regarded as good, in 10% as medium. As the frequency of local symptoms increases in correlation with the period of treatment, intramuscular co-trimoxazole should not be given longer than absolutely necessary.