[D-glucaric acid excretion in kidney transplant patients as an indicator of microsomal enzyme capacity]

The 24 hours excretion of D-glucaric acid in urine was determined in 53 male and 25 female renal transplant recipients to assess the microsomal enzyme activity in these patients. In male patients, the mean value of 73.1 mumoles/d (SD 43.6) as not significantly changed in comparison with healthy persons (70.9 mumol/d +/- 21.0). But the excretion of D-glucaric acid in female patients 68.3 mumoles/d +/- 37.5) was higher than in the control group (48.5 mumoles/d +/- 16.6). In comparison with the corresponding control groups, more female than male patients showed an increased and more men than women a decreased excretion of D-glucaric acid. These results indicate that changed microsomal enzyme activity and thus a changed drug metabolizing enzyme system has to be taken into account in patients after kidney transplantation.