[Evaluation of various cardiovascular parameters during the intravenous administration of ranitidine]

In this paper we evaluated whether a block of cardiac H2 histamine receptors by ranetidine could modify some non-invasive indices of cardiac function: PEP/LVET, heart rate, blood pressure. Five healthy volunteers underwent studies in baseline conditions and 5, 10, 15, 30, 45 minutes following i.v. injections of 1, 5 m/g Kg of ranitidine. None of the studied parameters showed any significant variation at the various time intervals. Ranetidine does not appear to alter the cardiovascular function at the dose we used.