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Beta 2-adrenoceptor agonists and thyroid hormones.

J P Kampmann, T L Svendsen, L Skovsted

    British Journal of Clinical Pharmacology
    |September 1, 1982
    PubMed
    Summary
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    Terbutaline, a beta 2-adrenoceptor agonist, does not significantly alter thyroid hormone levels in healthy individuals. Clinical contraindications in thyrotoxicosis stem from adverse reactions, not hormonal changes.

    Area of Science:

    • Endocrinology
    • Pharmacology

    Background:

    • Selective beta 2-adrenoceptor agonists like terbutaline are used for conditions such as asthma.
    • There is a clinical recommendation against using beta 2-adrenergic stimulating drugs in untreated thyrotoxicosis.

    Purpose of the Study:

    • To investigate the effect of terbutaline on serum thyroid hormone concentrations in healthy humans.
    • To determine if terbutaline influences thyroxine, triiodothyronine, and reverse triiodothyronine levels.

    Main Methods:

    • A study involving 11 healthy euthyroid subjects.
    • A control group (n=5) received no medication.
    • An experimental group (n=6) received 5 mg terbutaline three times daily for 2 weeks.

    Main Results:

    Related Experiment Videos

  • Serum concentrations of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3), and resin-triiodothyronine uptake (RTU) were measured.
  • No significant differences in these thyroid hormone parameters were observed between the terbutaline group and the control group.

    • Conclusions:

    • Terbutaline administration does not significantly affect serum thyroid hormone concentrations in healthy euthyroid individuals.
    • The contraindication of beta 2-adrenergic agonists in thyrotoxicosis is attributed to clinical adverse reactions, not direct effects on thyroid hormone levels.