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Updated: Aug 14, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
Published on: August 29, 2012
Graft-versus-host disease after treatment for chronic granulocytic leukaemia in transformation
Abstract:
Two patients with chronic granulocytic leukaemia in blast cell transformation treated with high-dose cytotoxic drugs and transfusion of cryopreserved chronic phase buffy coat stem cells developed a clinical and pathological syndrome that closely resembled graft-versus-host disease (GVHD). It was possible (1) that both patients had true GVHD resulting from transfusion of HLA-identical blood products, or (2) that both cases were examples of the 'pseudo-GVHD' seen by others following syngeneic transplants. The laboratory findings did not support one postulated pathogenetic mechanism for 'pseudo-GVHD'--namely a lack of suppressor T-lymphocytes.
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