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Asthma and beta-blockers.

D S Lawrence, J N Sahay, S S Chatterjee

    European Journal of Clinical Pharmacology
    |January 1, 1982
    PubMed
    Summary
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    For hypertensive patients with asthma, atenolol (a beta-blocker) is preferred over metoprolol. Atenolol effectively lowers blood pressure with significantly less asthma-related side effects.

    Area of Science:

    • Cardiology
    • Pulmonology
    • Clinical Pharmacology

    Background:

    • Hypertension management in asthmatic patients requires careful beta-blocker selection.
    • Beta-blockers can exacerbate asthma symptoms, necessitating a comparative analysis of different agents.

    Purpose of the Study:

    • To compare the effects of atenolol and metoprolol on blood pressure and bronchospasm in hypertensive patients with asthma.

    Main Methods:

    • A randomized, blind crossover study involving 14 hypertensive patients with asthma.
    • Equipotent doses of atenolol (100 mg daily) and metoprolol (100 mg twice daily) were administered for 3 weeks, with a placebo period.

    Main Results:

    • Both atenolol and metoprolol similarly reduced blood pressure.

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  • Atenolol demonstrated significantly less bronchospasm compared to metoprolol, indicated by fewer asthma attacks and improved asthma-free days.
  • Atenolol had a lesser impact on evening peak flow rate and reduced sensations of wheezing.

    • Conclusions:

    • Atenolol is the preferred beta-blocker for hypertensive patients with asthma due to its superior safety profile regarding respiratory side effects.
    • Co-prescription with a beta2 stimulant is recommended when using atenolol in this patient population.